2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus. New diagnostic criteria for systemic lupus erythematosus (SLE), released by the European and American rheumatology societies, helps to better distinguish patients with lupus from those with primary Sjögren’s syndrome, a study reports.. EVIDENCE BASED MEDICINE – SLICC criteria for SLE CMI 13:4 39 Oct 2015 Continued from page 38 Table 2. Consequently, the EULAR/ACR 2019 criteria have essentially come back to the NPSLE version of the ACR criteria . Of the analysed patients, 23.4%, 17.4% and 14.7% met the ACR 1997, SLICC 2012 and EULAR/ACR 2019 classification criteria for SLE at baseline, respectively. ... 249 (85%) patients fulfilled the 2012 SLICC criteria and 261 (89%) patients fulfilled the 1997 ACR criteria. The sensitivity and specificity of the EULAR/ACR 2019, SLICC 2012 and ACR 1982/1997 criteria were evaluated. The SLICC criteria for SLE classification requires: 1) Fulfillment of at least four criteria, with at least one clinical criterion AND one immunologic criterion OR 2) Lupus nephritis as the sole clinical criterion in the presence of ANA or anti-dsDNA antibodies. The 1997 update of the 1982 ACR revised criteria for the classification of SLE..... 12 Table 2. Clinical Criteria Acute Cutaneous Lupus OR Subacute Cutaneous Lupus. The honour is awarded to researchers who have made outstanding contributions to the ACR and the field of rheumatology through scholarly achievement and/or service to their patients, students, and profession. The accuracy of the EULAR/ACR-2019 criteria for SLE classification was the highest (diagnostic odds ratio [DOR], 243.2), followed by the SLICC-2012 criteria (DOR, 157.3) and the ACR-1997 criteria (DOR, 78.8). Systemic Lupus Erythematosus (SLE) V1.1.2019 iv List of Tables Table 1. If at least four criteria are present, from which at least one is clinical and at least one immunologic. The classification performance of each criteria was analyzed alone and in combination with additional features. In addition, patients who met the 2019 EULAR/ACR SLE criteria were significantly more likely to meet the ACR 1997 and SLICC criteria after an average follow-up of 9 years compared with the rest of the cohort (18.2% vs. 1.8%). Kyle Drehmel 1, Alan Erickson 1, Bryant England 2 and Michelene Hearth-Holmes 1, 1 University of Nebraska Medical Center, Omaha, NE, 2 VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha. Volume 49, Issue 3, Supplement, December 2019, Pages S14-S17. Recognition as a Master of the American College of Rheumatology is one of the highest honors the College bestows. This article is part of the Topical Collection onSystemic Lupus Erythematosus * Martin Aringer martin.aringer@uniklinikum-dresden.de Nicolai Leuchten The sensitivity and specificity of the EULAR/ACR 2019, SLICC 2012 and ACR 1982/1997 criteria were evaluated. Because of the extreme rarity of primary Sjögren syndrome in children, one may consider adding anti-Ro antibodies to the classification criteria for cSLE because they are present in ∼40% of patents with cSLE. Aringer M, Costenbader K, Daikh D, et al. Which of the following is included in the new 2019 ACR/EULAR systemic lupus erythematosus classification criteria, but not included in either the 1997 ACR criteria or 2017 SLICC criteria? SLICC clinical and immunologic classification criteria for systemic lupus ..... 14 Table 3. There was no significant difference in this proportion after follow-up. Ann Rheum Dis . The 2019 EULAR/ACR SLE classification criteria project has resulted in new, validated classification criteria [1,2].With EULAR and ACR support throughout the project and a symmetrically built 12 head steering committee (), this has been a large transatlantic, and in several stages truly worldwide effort.We now think that it has reached its goals. CONCLUSION: SLICC criteria were significantly more sensitive than ACR criteria in cSLE classification, especially early in the disease course. Results: Weighted SLICC criteria and the EULAR/ACR 2019 criteria had less sensitivity but better specificity compared to the list-based revised ACR 1997 and SLICC 2012 classification criteria. Published online 2019 Jun 5. The SLICC criteria added mononeuritis multiplex, myelitis and peripheral or cranial neuropathy , but all of these additional symptoms are uncommon and rarely important for classifying SLE. SLICC Criteria for the Classification of SLE* Criterion. CONCLUSIONS:The EULAR/ACR 2019 criteria perform well among patients with early disease, men, women, white, black, Hispanic and Asian patients. SLICC 2012 criteria performed better than EULAR/ACR 2019 criteria. Separation of different hematological manifestations in the SLICC 2012 criteria might have contributed to the higher performance of this criteria set. The sensitivity, specificity and accuracy of the different criteria are presented in table 2. Clinical criteria. International Collaborating Clinics (SLICC) criteria [7]and the new 2019 European League Against Rheumatism (EULAR)/ACR classification criteria [8†, 9†], discussing the rationale on the way. EULAR/ACR classification criteria for SLE. Acute cutaneous lupus: lupus malar rash (do not count if malar discoid), bullous lupus, toxic epidermal necrolysis variant of SLE, maculopapular lupus rash, photosensitive lupus rash (in the absence of dermatomyositis). Mucocutaneous Criteria To date there are no specific classification criteria for childhood-onset systemic lupus erythematosus (cSLE). Acute cutaneous lupus. Lupus nephritis as sole clinical criterion in the presence of ANA or anti-dsDNA antibodies. Classification criteria are used to identify homogeneous groups of patients for inclusion in research studies and clinical trials. These criteria have superior sensitivity than the ACR criteria and/or superior specificity than the SLICC criteria across many subgroups. This question is drawn from "2019 EULAR/ACR SLE Classification Criteria Offer Improved Sensitivity & Specificity," The Rheumatologist, December 2019. However, the 44 cases included by the ACR 97 criteria were served by the SLICC 12, that is, the SLICC 12 answered 14 more cases than the ACR 97 criteria. The 2012 SLICC Classification Criteria for SLE Classify a patient as having SLE if a) The patient satisfies four of the criteria, including at least one … The demographic characteristics are detailed in Table 2. ACR-97 criteria, with areas under the ROC curve of 0.801 and 0.780, respectively. The SLICC 2012 criteria yielded the best sensitivity, while the ACR 1997 criteria had the best specificity. The EULAR/American College of Rheumatology 2019 classification criteria for systemic lupus erythematosus did not perform significantly better than the ACR 1997 and SLICC 2012 criteria … The median time from first disease manifestation to criteria fulfillment was shorter for the EULAR/ACR 2019 criteria (28.47 months) than the 1997 ACR criteria (45.3 months, p. 0.001) and similar to the SLICC 2012 criteria (33.2 months, p=0.89). Conclusion Although the SLICC-12 criteria were superi-or to the ACR-97 and were more sensitive for diagnosing early SLE, their specificity in our population was too low. Meeting: 2019 ACR/ARP Annual Meeting Keywords: classification criteria, Clinical practice, systemic lupus erythematosus (SLE) and slicc, undifferentiated connective … Since, content-wise, additions have been relatively limited over time, we will use the single ACR criteria items to go over the changes implemented for the 2012 Systemic Lupus International Collaborating Clinics (SLICC) criteria and the new 2019 European League Against Rheumatism (EULAR)/ACR classification criteria [8•, 9•], discussing the rationale on the way. There were no statistically significant differences between any pair of rules with respect to overall agreement with the physician diagnosis. Neuropsychiatric manifestations of SLE were added in the 2012 SLICC classification criteria; disease definitions were refined to include delirium, psychosis, or seizure in the 2019 EULAR/ACR recommendations, and were evaluated for their sensitivity. The lupus criteria include a specific set of symptoms that your doctor can see, symptoms you report, your medical history, plus test results, to decide whether you have lupus. However, the mean SDI at last visit was lower among patients who never achieved the 2019 criteria, at 1.2 ± 1.7, compared with 2 ± 2.3 among those who did met the criteria (P = .0004). The sensitivity of the SLICC … Showing that the incidence in identifying the SLE using the SLICC 12 was higher than the ARC 97, making it possible to discover the disease at the beginning of the appearance of the first criterion. Lupus malar rash (malar discoid rash not counted), bullous lupus, toxic epidermal necrolysis variant of SLE, maculopapular lupus rash, photosensitive lupus rash (in the absence of … The comparison of the 2019 EULAR/ACR criteria with the earlier systems, researchers found, allowed for earlier SLE classification in 13.3% of cases when compared with the ACR 1982/1997 criteria, and in 15.3% of cases when evaluated against the 2012 SLICC criteria. Neuropsychiatric Criteria. The 2019 European League Against Rheumatism/American College of Rheumatology Classification for Systemic Lupus Erythematosus (EULAR/ACR). The new 2019 EULAR/ACR classification criteria for SLE requires a positive ANA as obligatory entry criterion. Other criteria were chosen from 7 clinical (constitutional, hematologic, neuropsychiatric, mucocutaneous, serosal, musculoskeletal, renal) and 3 immunologic (antiphospholipid antibodies, complement proteins, SLE-specific antibodies) categories, and weighted from 2 to 10. 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