Am J Clin Nutr 2004;80:1710S-6S. We encourage you to talk to your healthcare providers (doctor, registered dietitian, pharmacist, etc.) Vitamin D supplements and prevention of cancer and cardiovascular disease. Curr Opin Endocrinol Diabetes 2002;9:87-98. [, Singh P, Trivedi N. Tanning beds and hypervitaminosis D: A case report. Osteoporosis is most often associated with inadequate calcium intakes, but insufficient vitamin D intakes contribute to osteoporosis by reducing calcium absorption [1]. High serum cholesterol levels and hypertension are two of the main risk factors for CVD. Cancer Epidemiol Biomarkers Prev 2019;28:900-8. Rickets occurred mainly in Black children who were breastfed longer, were born with low birthweight, weighed less, and were shorter than other children. [, Moyer VA. Vitamin, mineral, and multivitamin supplements for the primary prevention of cardiovascular disease and cancer: U.S. Preventive Services Task Force recommendation statement. Clin Gastroeterol Hepatol 2020; published online ahead of print. An investigation that pooled data from 10 studies of cancer in 12,205 men and women found that concentrations of 25(OH)D greater than 75 nmol/L (30 ng/mL) but less than 100 nmol/L (40 ng/mL) did not reduce the risk of pancreatic cancer. a suffix of nouns that have the general sense “offspring of, descendant of,” occurring orig. The U.S. Preventive Services Task Force (USPSTF) found insufficient evidence to assess the benefits and harms of screening for vitamin D deficiency in asymptomatic adults [6]. Further research is needed to determine whether vitamin D inadequacy increases cancer risk, whether greater exposure to the nutrient can prevent cancer, and whether some individuals could have an increased risk of cancer because of their vitamin D status over time. Nutrients 2018, 10, 59; doi:10.3390/nu10010059. [. Glucocorticoid-induced osteoporosis: pathogenesis and management. Vitamin D has other roles in the body, including reduction of inflammation as well as modulation of such processes as cell growth, neuromuscular and immune function, and glucose metabolism [1-3]. Furthermore, the bone health of older Black American women does not appear to benefit from raising serum 25(OH)D levels beyond 50 nmol/L (20 ng/mL) [84]. Int J Obes Relat Metab Disord 1997;21:S24-30. [, Malihi Z, Lawes CMM, Wu Z, Huang Y, Waayer D, Toop L, et al. Sempos CT, Carter GD, Binkley NC. A case-control analysis of 1,695 cases of prostate cancer and 1,682 controls found no associations between 25(OH)D levels and prostate cancer risk [110]. The trials administered different amounts of vitamin D (ranging from 10 mcg [400 IU]/day to 1,000 mcg [40,000 IU]/week). The results showed no significant differences in rates of progression to type 2 diabetes; in serum glucose, insulin, or hemoglobin A1c levels; or in measures of insulin resistance. Vitamin D toxicity has been caused by consumption of dietary supplements that contained excessive vitamin D amounts because of manufacturing errors, that were taken inappropriately or in excessive amounts, or that were incorrectly prescribed by physicians, [155-157]. Obtaining sufficient vitamin D from natural (nonfortified) food sources alone is difficult. Diets low in vitamin D are more common in people who have milk allergy or lactose intolerance and those who consume an ovo-vegetarian or vegan diet [1]. Am J Clin Nutr 2004;80:1697S-705S. Silva MC, Furlanetto TW. Bone health and osteoporosis U.S. Department of Health and Human Services. For infants, the FNB committee developed AIs based on the amount of vitamin D that maintains serum 25(OH)D levels above 20 ng/mL (50 nmol/L) and supports bone development. Mayo Clin Proc 2013;88:720-55. JAMA 2018;319:1630. Vitamin D supplementation to reduce depression in adults: Meta-analysis of randomized controlled trials. 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